ZNF496 antibody

Catalog No. ABIN2461953

Product Details anti-ZNF496 Antibody

Target: ZNF496 (Zinc Finger Protein 496 (ZNF496))

Reactivity: Mouse, Human, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF496 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ZNF496.

Application Details

Application Notes: ZNF496 antibody can be used for detection of ZNF496 by ELISA at 1:62500. ZNF496 antibody can be used for detection of ZNF496 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store ZNF496 antibody at -20 °C.

Target Details for ZNF496

Target: ZNF496 (Zinc Finger Protein 496 (ZNF496))

Alternative Name: ZNF496 (ZNF496 Products)

Background: ZNF496 contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C2HR motif. The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn (II)-dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner. ZNF496 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remnant of a C2H2 motif.

Molecular Weight: 67 kDa

Gene ID: 84838

NCBI Accession: NP_116141

UniProt: Q96IT1