TCAP antibody

Catalog No. ABIN2463159

The Rabbit Polyclonal anti-TCAP antibody (ABIN2463159) specifically detects TCAP in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TCAP antibody (ABIN2463159)

Target: TCAP (Titin-Cap (Telethonin) (TCAP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCAP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TCAP Antibody

Purification: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TCAP.

Application Details

Application Notes: TCAP antibody can be used for detection of TCAP by ELISA at 1:62500. TCAP antibody can be used for detection of TCAP by western blot at 5.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store TCAP antibody at -20 °C.

Target Details for TCAP

Target: TCAP (Titin-Cap (Telethonin) (TCAP))

Alternative Name: TCAP

Background: Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. TCAP is a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in TCAP gene are associated with limb-girdle muscular dystrophy type 2G.Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Molecular Weight: 19 kDa

Gene ID: 8557

NCBI Accession: NP_003664

UniProt: O15273