SGK3 antibody (C-Term)

Catalog No. ABIN2469462

The Rabbit Polyclonal anti-SGK3 antibody (ABIN2469462) specifically detects SGK3 in IHC and ELISA. The antibody is reactive with Human, Rabbit, Monkey, Gibbon, Gorilla and Orang-Utan samples.

Quick Overview for SGK3 antibody (C-Term) (ABIN2469462)

Target: SGK3 (serum/glucocorticoid Regulated Kinase Family, Member 3 (SGK3))

Reactivity: Human, Rabbit, Monkey, Gibbon, Gorilla, Orang-Utan

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGK3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-SGK3 Antibody

Binding Specificity: C-Term

Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SGK1 (59 % ).

Purification: Immunoaffinity Chromatography

Immunogen: SGK3 antibody was raised against a peptide located in the C-Terminal domain of SGK3 (Human).

Application Details

Application Notes: SGK3 antibody can be used in immunohistochemistry starting at 14 - 28 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-80 °C

Storage Comment: SGK3 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Target Details for SGK3

Target: SGK3 (serum/glucocorticoid Regulated Kinase Family, Member 3 (SGK3))

Alternative Name: SGK3

Background: SGKL/SGK3, also known as CISK for cytokine-independent survival kinase, is a SGK type protein kinase. The protein contains a lipid-binding phox homology (PX) domain, which is required for targeting SGKL/SGK3 protein to the endosomal compartment. SGKL/SGK3 functions downstream of the phosphoinositide 3-kinase (PI3K) cascade and has been implicated in cell survival. The protein has been shown to be phosphorylated and activated by 3-phosphoinositide-dependent protein kinase 1 (PDK1), and to a lesser extent insulin-like growth factor-1, in vitro. Activated SGKL/SGK3 has been shown to phosphorylate glycogen synthase kinase 3 beta (GSK-3beta) in vitro.

Gene ID: 23678

UniProt: Q96BR1