HAVCR1 antibody (AA 200-300)

Catalog No. ABIN2470107

This anti-HAVCR1 antibody is a Rabbit Polyclonal antibody detecting HAVCR1 in WB, IHC. Suitable for Human, Mouse.

Quick Overview for HAVCR1 antibody (AA 200-300) (ABIN2470107)

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAVCR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-HAVCR1 Antibody

Binding Specificity: AA 200-300

Purification: Protein G Column

Immunogen: HAVCR1 antibody was raised against amino acids 200 - 300 of HAVCR1 (Human).

Isotype: IgG

Application Details

Application Notes: HAVCR1 antibody can be used in immunohistochemistry starting at 5 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.05 % BSA, 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store HAVCR1 antibody at 4 °C for short term applications. For long term storage, aliquot and -20 °C.

Target Details for HAVCR1

Target: HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))

Alternative Name: HAVCR1

Target Type: Virus

Background: HAVCR1, a 359 A.A Class 1 integral membrane glycoprotein, is used by Hepatitis A virus to infect humans. It consists of a conserved N-terminal Cys-rich region, IgV (Immunoglobulin Variable region like) domain and a TSP-rich mucin domain in the extracellular region followed by a highly conserved tyrosine kinase phosphorylation motif in the cytoplasmic region. HAVCR1 is expressed on terminally differentiated CD4+ Th2 cells and regulates cytokine production. It plays an important role in the regulation of immune responses in the development of asthma and allergic responses. Its expression is critically upregulated in dedifferentiated kidney cells, thus indicating a possible role in regeneration of proximal tubule epithelium in Kidneys. HAVCR1 has shown to be upregulated in renal carcinomas, suggesting its role in tumor progression and metastasis.

Gene ID: 26762

UniProt: Q96D42