PTH1R antibody (pThr1)

Catalog No. ABIN2470513

This Mouse Monoclonal antibody specifically detects PTH1R in WB and IHC. It exhibits reactivity toward Human, Cow, Pig, Dog, Monkey, Horse, Gibbon, Gorilla and Orang-Utan.

Quick Overview for PTH1R antibody (pThr1) (ABIN2470513)

Target: PTH1R (Parathyroid Hormone 1 Receptor (PTH1R))

Reactivity: Human, Cow, Pig, Dog, Monkey, Horse, Gibbon, Gorilla, Orang-Utan

Host: Mouse

Clonality: Monoclonal

Conjugate: This PTH1R antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PTH1R Antibody

Binding Specificity: pThr1

Specificity: Recognizes human PTH/PTHrP receptor, Mr 80kD, and the receptor dimer, Mr 160kD. A faint nonspecific band at 110kD is also detected. This antibody does not detect the PTH2 receptor.

Purification: Protein G Column

Immunogen: PTHR1 monoclonal antibody was raised against a synthetic peptide corresponding to aa 146 - 169 of PTHR1 (Human).

Isotype: IgG1 kappa

Application Details

Application Notes: PTHR1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 15 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.6, 0.07 % sodium azide, 30 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Product should be stored long term (months) at -20 °C and short term (weeks) at 4 °C.

Target Details for PTH1R

Target: PTH1R (Parathyroid Hormone 1 Receptor (PTH1R))

Alternative Name: PTHR1

Background: PTHR1, a Parathyroid Hormone Receptor, mediates PTH-dependent regulation of mineral-ion homeostasis. It also mediates the paracrine action of PTHRP in endochondral bone formation. Mutations in this receptor are responsible for disorders of calcium and bone metabolism such as chondrodysplasia, hypercalcemia, and chronic renal failure. Three promoters, P1, P2, and P3, regulate the expression of PTHR.

Gene ID: 5745

UniProt: Q03431

Pathways: Regulation of Carbohydrate Metabolic Process