Transferrin antibody (N-Term)

Catalog No. ABIN2476916

The Mouse Monoclonal anti-Transferrin antibody is suitable to detect Transferrin in samples from Human, Rat, Pig and Rabbit. It has been validated for WB, ELISA, IF and Func.

Quick Overview for Transferrin antibody (N-Term) (ABIN2476916)

Target: Transferrin (TF)

Reactivity: Human, Rat, Pig, Rabbit

Host: Mouse

Clonality: Monoclonal

Conjugate: This Transferrin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Functional Studies (Func)

Clone: HTF-14

Product Details anti-Transferrin Antibody

Binding Specificity: N-Term

Specificity: Anti transferrin clone HTF-14 is specific for the N-terminal domain of human transferrin and has been shown to block binding of transferrin to the transferrin receptor (CD71). Clone HTF-14 is not able to recognise receptor bound transferrin. Clone HTF-14 recognises a conformational epitope in a loop of the N lobe of transferrin involving the critical Lys-144 residue, also essential for binding of the N lobe to the transferrin receptor (Mason et al.2009)Transferrin is a 77 kDa plasma protein synthesized by the liver involved with the transport of iron. Each transferrin molecule has two domains, both with facility to carry 2 ferric ions. The iron/transferrin complex is essential for haemoglobin synthesis and certain types of cell division.

Cross-Reactivity: Pig (Porcine), Rabbit, Rat (Rattus)

Characteristics: Purified IgG

Purification: Purified

Immunogen: Purified porcine transferrin

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Target Details for Transferrin

Target: Transferrin (TF)

Alternative Name: TRANSFERRIN

Gene ID: 7018

UniProt: P02787

Pathways: Transition Metal Ion Homeostasis