CD28 antibody

Catalog No. ABIN2479686

This anti-CD28 antibody is a Mouse Monoclonal antibody detecting CD28 in FACS and Func. Suitable for Mouse. This Primary Antibody has been cited in 3+ publications.

Quick Overview for CD28 antibody (ABIN2479686)

Target: CD28

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD28 antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: E18

Product Details anti-CD28 Antibody

Characteristics: Purified IgG

Endotoxin Level: Low endotoxin

Immunogen: Alternate immunisation with A20 cells expressing mCD28 and recombinant mCD28Ig.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

References for anti-CD28 antibody (ABIN2479686)

Gogishvili, Lühder, Kirstein, Nieuwenhuizen, Goebbels, Beer-Hammer, Pfeffer, Reuter, Taube, Brombacher, Hünig: "Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease." in: The Journal of allergy and clinical immunology, Vol. 130, Issue 6, pp. 1394-403.e4, (2012) (PubMed).

Beyersdorf, Ding, Blank, Dennehy, Kerkau, Hünig: "Protection from graft-versus-host disease with a novel B7 binding site-specific mouse anti-mouse CD28 monoclonal antibody." in: Blood, Vol. 112, Issue 10, pp. 4328-36, (2008) (PubMed).

Dennehy, Elias, Zeder-Lutz, Ding, Altschuh, Lühder, Hünig: "Cutting edge: monovalency of CD28 maintains the antigen dependence of T cell costimulatory responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 10, pp. 5725-9, (2006) (PubMed).

Target Details for CD28

Target: CD28

Alternative Name: CD28

Gene ID: 12487

UniProt: P31041

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response