tau antibody (pSer202, pSer519)

Catalog No. ABIN2568469

The Rabbit Polyclonal anti-tau antibody (ABIN2568469) specifically detects tau in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for tau antibody (pSer202, pSer519) (ABIN2568469)

Target: tau (tau Protein)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This tau antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-tau Antibody

Binding Specificity: pSer202, pSer519

Specificity: The antibody detects endogenous levels of Tau only when phosphorylated at serine 519/202.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: Tau (phospho Ser519/202) antibody was raised against a peptide sequence around phosphorylation site of Serine 519/202 (P-G-S (p)-P-G) derived from Human Tau.

Isotype: IgG

Application Details

Application Notes: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for tau

Target: tau (tau Protein)

Alternative Name: tau

Background: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Molecular Weight: 85 kDa

Gene ID: 4137

NCBI Accession: NP_058519

UniProt: P10636