ADRA2B antibody

Catalog No. ABIN264463

This Mouse Monoclonal antibody specifically detects ADRA2B in WB and IHC (fro). It exhibits reactivity toward Rat and Mouse.

Quick Overview for ADRA2B antibody (ABIN264463)

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Reactivity: Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This ADRA2B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 5G10

Product Details anti-ADRA2B Antibody

Characteristics: Synonyms: ADRA2B, ADRA2L1, ADRA2RL1, Alpha-2B adrenoreceptor, Alpha-2B adrenoceptor

Purification: Purified

Immunogen: Antibody raised to synthetic peptide internal sequence corresponding to the thirdintracellular loop of rat alpha 2b adrenergic receptor.

Isotype: IgG1

Application Details

Application Notes: Western blot (1-5 μg/mL). Immunohistochemistry. Positive Control/Tissue Expression: MDCK cells transfected with rat alpha2B adrenergicreceptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.08 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Expiry Date: 12 months

Target Details for ADRA2B

Target: ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))

Alternative Name: alpha-2B Adrenergic Receptor

Background: The rat alpha 2b adrenergic receptor is a G protein coupled receptor which acts through Gi2 and is responsible for Cellular communication and signal transduction. These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtypes of alpha(2)-AR were described, alpha(2A)-AR, alpha(2B)-AR and alpha(2C)-AR. At present, it is unknown which of these alpha(2)-AR subtype(s) may regulate insulin secretion.Synonyms: ADRA2B, ADRA2L1, ADRA2RL1, Alpha-2B adrenoceptor, Alpha-2B adrenoreceptor

Gene ID: 24174

UniProt: P19328

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process