S1PR4 antibody (C-Term)

Catalog No. ABIN265012

This Rabbit Polyclonal antibody specifically detects S1PR4 in WB. It exhibits reactivity toward Human.

Quick Overview for S1PR4 antibody (C-Term) (ABIN265012)

Target: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S1PR4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-S1PR4 Antibody

Binding Specificity: C-Term

Specificity: This antibody recognizes Human EDG-6 / S1P4 / S1PR4. Other species not tested.

Purification: Purified

Immunogen: Synthetic peptide derived from the C-terminal of the EDG-6 receptor.

Application Details

Application Notes: Western Blot: Detects EDG-6 receptors at concentration of 5-10 μg/mL by Western blotusing a human EDG-6 receptor transfected cell line. Detects an approximately 45 kDa bandin Cos cells transfected with full length human EDG-6. Due to low expression of EDGreceptors, we recommend use of Pierce Femto Signal substrate for western blotdevelopment.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS, 0.08 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for S1PR4

Target: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Alternative Name: S1PR4 / EDG6

Background: EDG-6 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-6 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-6 is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG-6 receptor is the sphingosine 1-phosphate receptor-4 (S1P-4).Synonyms: EDG-6, Endothelial differentiation G-protein coupled receptor 6, S1P receptor Edg-6, Sphingosine 1-phosphate receptor 4, Sphingosine 1-phosphate receptor Edg-6

Gene ID: 8698

NCBI Accession: NP_003766

UniProt: O95977