SH2D1A antibody

Catalog No. ABIN265020

This anti-SH2D1A antibody is a Rabbit Polyclonal antibody detecting SH2D1A in WB and IP. Suitable for Human.

Quick Overview for SH2D1A antibody (ABIN265020)

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH2D1A antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-SH2D1A Antibody

Specificity: This antibody reacts to SH2D1A.

Purification: Purified

Immunogen: Full-length recombinant SAP protein

Isotype: IgG

Application Details

Application Notes: Western Blot: 5 - 10 μg/mL. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for SH2D1A

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Alternative Name: SH2D1A

Background: SLAM (Signaling Lymphocyte-Activation Molecule) is a glycosylated type-I transmembrane protein which is present on the surface of B and T cells. SLAM is a high-affinity self-ligand which, when triggered, co-activated B or T lymphocyte responses and is considered to be important in bi-directional T - B cell stimulation. SAP (SLAM-Associated Protein) has been determined to be a 15 kDa protein. SAP is believed to the genetic defect which cauases X-linked Lymphoproliferative Syndrome (XLP). SAP is thought to bind to SLAM by the SH2 domain of the SAP protein. Binding of SAP to the SLAM protein blocks the binding of SHP-2 to the phosphorylated SLAM protein which causes XLP.Synonyms: DSHP, Duncan disease SH2-protein, SAP, SH2 domain-containing protein 1A, SLAM-associated protein, Signaling lymphocytic activation molecule-associated protein, T-cell signal transduction molecule SAP

Gene ID: 4068

NCBI Accession: NP_001108409

UniProt: O60880

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process