S1PR3 antibody (N-Term)

Catalog No. ABIN265059

The Rabbit Polyclonal anti-S1PR3 antibody (ABIN265059) specifically detects S1PR3 in WB. The antibody is reactive with Human samples.

Quick Overview for S1PR3 antibody (N-Term) (ABIN265059)

Target: S1PR3 (Sphingosine-1-Phosphate Receptor 3 (S1PR3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S1PR3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-S1PR3 Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to EDG-3 / S1P3 / S1PR3.

Purification: Purified

Immunogen: Synthetic peptide derived from the N terminal of the EDG3 (S1P3) protein.

Application Details

Application Notes: Western Blot: 5 - 10 μg/mL, Due to low expression of EDG receptors, we recommend use ofPierce Femto Signal substrate for western blot development.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for S1PR3

Target: S1PR3 (Sphingosine-1-Phosphate Receptor 3 (S1PR3))

Alternative Name: EDG-3 / S1P3

Background: Endothelial cell differentation gene-3 (EDG3) belongs to a family of G-protein couple receptors whose ligands are lysophospholipids. The ligand for EDG3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family. They have been implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG3 is expressed in cardiovascular, leukocyte-containing and other tissues.Synonyms: EDG3, Endothelial differentiation G-protein coupled receptor 3, FLJ37523, FLJ93220, LPB3, MGC71696, S1P receptor 3, S1PR3, Sphingosine 1-phosphate receptor 3

Gene ID: 1903

NCBI Accession: NP_005217

UniProt: Q99500