Adiponectin Receptor 1 antibody

Catalog No. ABIN265109

The Rabbit Polyclonal anti-Adiponectin Receptor 1 antibody is suitable to detect Adiponectin Receptor 1 in samples from Human. It has been validated for WB and EIA.

Quick Overview for Adiponectin Receptor 1 antibody (ABIN265109)

Target: Adiponectin Receptor 1 (ADIPOR1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adiponectin Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-Adiponectin Receptor 1 Antibody

Specificity: This antibody recognizes Adiponectin Receptor 1.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from Human Adiponectin Receptor 1 protein.

Application Details

Application Notes: Western Blot: 5-10 μg/mL. Positive Control: Highly expressed in skeletal muscle. Expressed at intermediate level inbrain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline with 0.08 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for Adiponectin Receptor 1

Target: Adiponectin Receptor 1 (ADIPOR1)

Alternative Name: Adiponectin Receptor 1

Background: Alzheimer's disease (AD) is characterized by formation of plaques of amyloid beta peptide (Abeta). Autosomally-inherited AD had been shown only in connection with coding sequence mutations. Likely transcription factors whose mutation can cause loss of function are ADR1, MIG1, and PuF, and for gain of function, E12/E47, ITF-2, and RFX2. Adr1 controls the expression of genes required for ethanol, glycerol, and fatty acid utilization (in yeast). Adr1 can act directly on the promoters of ADH2, ACS1, GUT1, CTA1, and POT1. The yeast homolog of the AMP-activated protein kinase, Snf1, promotes Adr1 chromatin binding in the absence of glucose, and the protein phosphatase complex, Glc7.Reg1, represses its binding in the presence of glucose. A post-translational process is invloved in the regulation of Adr1 binding. Chromatin binding by Adr1 is not the only step in ADH2 transcription that is regulated by glucose repression, Adr1 can bind to chromatin in repressed conditions in the presence of hyperacetylated histones. In yeast, nuclear extracts prepared from glucose-repressed and glucosederepressed cells are equally capable of supporting miniAdr1-dependent transcription and pre-initiation complex formation.Synonyms: ADIPOR1, CGI-45, PAQR1, Progestin and adipoQ receptor family member I

Gene ID: 51094

NCBI Accession: NP_001121159

UniProt: Q96A54

Pathways: AMPK Signaling