Clusterin antibody (Isoform 1)

Catalog No. ABIN265125

The Rabbit Polyclonal anti-Clusterin antibody (ABIN265125) specifically detects Clusterin in WB. The antibody is reactive with Human samples.

Quick Overview for Clusterin antibody (Isoform 1) (ABIN265125)

Target: Clusterin (CLU)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Clusterin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Clusterin Antibody

Binding Specificity: Isoform 1

Specificity: This antibody reacts to Apolipoprotein J (Clusterin).

Purification: Purified

Immunogen: Rabbit polyclonal Clusterin antibody was raised recombinant human Clusterin isoform 1.

Isotype: IgG

Application Details

Application Notes: Western Blot: 0.5 - 1 μg/mL. Positive Control: Human Brain Tissue Lysate used as positive control. Clusterin is known tobe expressed in a variety of tissues and it seems to be able to bind to cells, membranesand hydrophobic proteins.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for Clusterin

Target: Clusterin (CLU)

Alternative Name: Apolipoprotein J (Apo J)

Background: Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer's b-amyloid peptide (1). Clusterin expression is increased in Alzheimer's disease brain tissue and clusterinimmunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites (2) and it has been suggested that clusterin facilitates the conversion of diffuse bamyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression (3). Clusterin exists in at least two distinct isoforms.Synonyms: 40, 40, AAG4, APOJ, Aging-associated gene 4 protein, CLI, Clusterin, Complement cytolysis inhibitor, Complement-associated protein SP-40, KUB1, Ku70-binding protein 1, NA1/NA2, SP-40, Testosterone-repressed prostate message 2

Gene ID: 1191

NCBI Accession: NP_976084

UniProt: P10909

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling