IRF7 antibody (C-Term)

Catalog No. ABIN265129

This Rabbit Polyclonal antibody specifically detects IRF7 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for IRF7 antibody (C-Term) (ABIN265129)

Target: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IRF7 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to Interferon Regulatory Factor 7 (IRF7). Expressed predominantly in spleen, thymus and peripheral blood leukocytes, IRF7 is located in the nucleus and cytoplasm. The phosphorylated and active form accumulates selectivly in the nucleus.

Purification: Purified

Immunogen: Peptide corresponding to 14 amino acids near the carboxy-terminus of Human IRF7

Isotype: IgG

Application Details

Application Notes: Western Blot: 1-2 μg/mL. Positive control: Spleen, thymus and peripheral blood leukocytes.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline with 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for IRF7

Target: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Alternative Name: IRF7

Background: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.Synonyms: IRF-7, Interferon regulatory factor 7

Gene ID: 3665

NCBI Accession: NP_001563

UniProt: Q92985

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy