IRF7 antibody (Alexa Fluor 647)

Catalog No. ABIN2657216

This anti-IRF7 antibody is a Mouse Monoclonal antibody detecting IRF7 in FACS. Suitable for Human.

Quick Overview for IRF7 antibody (Alexa Fluor 647) (ABIN2657216)

Target: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IRF7 antibody is conjugated to Alexa Fluor 647

Application: Flow Cytometry (FACS)

Clone: 12G9A36

Product Details anti-IRF7 Antibody (Alexa Fluor 647)

Purification: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C

Target Details for IRF7

Target: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Alternative Name: IRF7

Background: IRF-7 is a member of the interferon regulatory transcription factor family that plays key regulatory roles in innate immunity. Upon virus infection, IRF-7 forms a complex with MyD88 and TRAF6 when stimulated by toll-like receptors TLR7, TLR8, and TLR9, which in turn results in nuclear translocation and induction of interferon gene expression. IRF-7 gene expression is upregulated by the stimulation of interferon through the Jak-STAT signaling pathway, which forms a positive feedback loop. The protein level of IRF-7 after activation is then downregulated by the ubiquitin-proteasome system to avoid excessive production of interferons that may cause damage to the host. Virus induced type I interferon expression was completely abrogated in IRF-7 knockout mice, suggesting that IRF-7 is critical for interferon mediated host defense during virus infection.

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy