NOTCH2 antibody (APC)

Catalog No. ABIN2658814

The Hamster Monoclonal anti-NOTCH2 antibody has been validated for FACS. It is suitable to detect NOTCH2 in samples from Mouse.

Quick Overview for NOTCH2 antibody (APC) (ABIN2658814)

Target: NOTCH2 (Notch 2 (NOTCH2))

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This NOTCH2 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: HMN2-35

Product Details anti-NOTCH2 Antibody (APC)

Purification: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for NOTCH2

Target: NOTCH2 (Notch 2 (NOTCH2))

Alternative Name: Notch 2

Background: The Notch receptors are highly conserved from invertebrates to mammals.While Notch1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences.The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus.This translocation triggers a series of signaling process.Notch 3 is primarily expressed in adult arterial smooth muscle cells.Notch 3 gene mutation can cause CADASIL, an inherited early stroke syndrome.

Pathways: Notch Signaling, Stem Cell Maintenance