NOTCH2 antibody (APC)

Catalog No. ABIN2658816

This Mouse Monoclonal antibody specifically detects NOTCH2 in BCA. It exhibits reactivity toward Human.

Quick Overview for NOTCH2 antibody (APC) (ABIN2658816)

Target: NOTCH2 (Notch 2 (NOTCH2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NOTCH2 antibody is conjugated to APC

Application: Biochemical Assay (BCA)

Clone: MHN2-25

Product Details anti-NOTCH2 Antibody (APC)

Purification: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for NOTCH2

Target: NOTCH2 (Notch 2 (NOTCH2))

Alternative Name: Notch 2

Background: The Notch receptors are a type I transmembrane protein family that share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. They are highly conserved from invertebrates to mammals. Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors (Notch 1-4). Notch 1 and Notch 2 are reported to be functionally redundant. Notch 2 is expressed by Pre-B cells, double negative, and CD8 single positive thymocytes, brain, and lung cells. Notch 2 functions as a receptor for Jagged and Delta ligands and may play a role in vascular, renal and hepatic development.

Pathways: Notch Signaling, Stem Cell Maintenance