ICOS antibody (PE-Cy5)

Catalog No. ABIN2658951

This Hamster Monoclonal antibody specifically detects ICOS in ELISA (Capture) and CyTOF. It exhibits reactivity toward Mouse.

Quick Overview for ICOS antibody (PE-Cy5) (ABIN2658951)

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This ICOS antibody is conjugated to PE-Cy5

Application: ELISA (Capture), Cytometry by Time of Flight (CyTOF)

Clone: 15F9

Product Details anti-ICOS Antibody (PE-Cy5)

Purification: The antibody was purified by affinity chromatography, and conjugated with PE/Cy5 under optimal conditions. The solution is free of unconjugated PE/Cy5 and unconjugated antibody.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for ICOS

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Alternative Name: CD278

Background: CD278 is a 47-57 kD protein, also known as inducible costimulatory molecule (ICOS), or H4. This protein is homologous to the CD28/CTLA-4 proteins. It forms homodimers and is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. It has also been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.

Pathways: Cancer Immune Checkpoints