Neuropilin 1 antibody (PE-Cy7)

Catalog No. ABIN2659227

This Rat Monoclonal antibody specifically detects Neuropilin 1 in WB. It exhibits reactivity toward Mouse.

Quick Overview for Neuropilin 1 antibody (PE-Cy7) (ABIN2659227)

Target: Neuropilin 1 (NRP1)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Neuropilin 1 antibody is conjugated to PE-Cy7

Application: Western Blotting (WB)

Clone: 3E12

Product Details anti-Neuropilin 1 Antibody (PE-Cy7)

Purification: The antibody was purified by affinity chromatography and conjugated with PE/Cy7 under optimal conditions. The solution is free of unconjugated PE/Cy7 and unconjugated antibody.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for Neuropilin 1

Target: Neuropilin 1 (NRP1)

Alternative Name: CD304

Background: CD304, also known as neuropilin-1, is a 140 kD type I transmembrane protein. Its extracellular region contains two CUB, two FV/FVIII, and one MAM domain. It is expressed by natural regulatory T cells (nTreg), a subset of invariant natural killer T cells (iNKT), endothelial cells, and neurons. Neuropilin-1 stabilizes the interaction between Tregs and dendritic cells, contributes to the recruitment of tumor-infiltrating Tregs in response to tumor-derived VEGF, and influences the process of angiogenesis and axon guidance. The ligands of CD304 are VEGF165 and semaphorin-3A.

Pathways: Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals