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CD51 antibody

This Mouse Monoclonal antibody specifically detects CD51 in ICFC. It exhibits reactivity toward Human.
Catalog No. ABIN2664759

Quick Overview for CD51 antibody (ABIN2664759)

Target

See all CD51 (ITGAV) Antibodies
CD51 (ITGAV) (Integrin alpha V (ITGAV))

Reactivity

  • 139
  • 57
  • 25
  • 17
  • 5
  • 5
  • 5
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human

Host

  • 75
  • 64
  • 10
  • 1
Mouse

Clonality

  • 87
  • 62
Monoclonal

Conjugate

  • 83
  • 10
  • 8
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This CD51 antibody is un-conjugated

Application

  • 78
  • 63
  • 57
  • 46
  • 34
  • 25
  • 21
  • 14
  • 14
  • 14
  • 12
  • 8
  • 4
  • 4
  • 2
  • 1
  • 1
Intracellular Flow Cytometry (ICFC)

Clone

NKI-M9
  • Purification

    The antibody was purified by affinity chromatography.

    Isotype

    IgG2a kappa
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Concentration

    0.5 mg/mL

    Buffer

    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Storage Comment

    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target

    CD51 (ITGAV) (Integrin alpha V (ITGAV))

    Alternative Name

    CD51

    Background

    CD51 is a type I integral membrane glycoprotein, known as vitronectin receptor α chain, or integrin αV. It forms heterodimer with integrin β1(CD29), β3 (CD61), β5, β6, or β8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD, and is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its β chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling, mediates bone absorption and angiogenesis.

    Pathways

    Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex
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