CD77 antibody

Catalog No. ABIN2664821

The Mouse Monoclonal anti-CD77 antibody has been validated for FACS. It is suitable to detect CD77 in samples from Human.

Quick Overview for CD77 antibody (ABIN2664821)

Target: CD77

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD77 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 5B5

Product Details anti-CD77 Antibody

Purification: The antibody was purified by affinity chromatography.

Isotype: IgM kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CD77

Target: CD77

Background: CD77, also known as Gb3S, A14GALT, A4GALT1, is a type II membrane protein. It was found specifically expressed on Burkitt's lymphoma cells and on a subset of germinal center B lymphocytes. CD77 has been described as a receptor for Shiga Toxin and Verotoxin 1 (VT1), which is produced by Shigella dysenteriae and some strains of E. coli . It is used as a marker for germinal center stage B-cells. CD19 has been reported as a ligand for D77 and their interaction functions in adhesion and signal transduction at a specific stage of B cell development. Studies have shown that cross-linking CD77 induces apoptosis in some B cell lines.