IL33RA antibody

Catalog No. ABIN2665164

The Rat Monoclonal anti-IL33RA antibody (Clone DIH9) (ABIN2665164) specifically detects IL33RA in IHC, FACS, BR and CyTOF. The antibody is reactive with Mouse samples.

Quick Overview for IL33RA antibody (ABIN2665164)

Target: IL33RA (Interleukin 33 Receptor alpha (IL33RA))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Blocking Reagent (BR), Cytometry by Time of Flight (CyTOF)

Clone: DIH9

Product Details anti-IL33RA Antibody

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for IL33RA

Target: IL33RA (Interleukin 33 Receptor alpha (IL33RA))

Alternative Name: IL-33R alpha

Background: IL-33Rα, also known as ST2 or IL-1RL1, is a member of the Toll/IL-1 receptor family. It binds IL-33 and is structurally similar to IL-1R1. Two forms of the protein exist - a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis has been reported to be important across a range of diseases including asthma, allergies, and cardiac disease.