Thrombomodulin antibody

Catalog No. ABIN2688974

This Mouse Monoclonal antibody specifically detects Thrombomodulin in FACS, IHC (fro) and FM. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for Thrombomodulin antibody (ABIN2688974)

Target: Thrombomodulin (THBD)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Thrombomodulin antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Fluorescence Microscopy (FM)

Clone: 1A4

Product Details anti-Thrombomodulin Antibody

Brand: BD Pharmingen™

Characteristics: Reacts with a 75 kDa, a single chain, type I membrane glycoprotein referred to as thrombomodulin and fetomodulin. CD141 is expressed on endothelial cells, smooth muscle cells, epithelial cells, synovial lining cells, and keratinocytes. It is also found on megakaryocytes, peripheral blood moncytes, and neutrophils, but not on lymphocytes. Reports indicate that CD 141 plays an important role in Protein C activation and the initiation of the Protein C anticoagulant pathway. Thrombin loses its procagulant function when it binds to CD141, and the CD141/thrombin complex is able to activate Protein C. This product is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood monocytes analyzed by flow cytometry.

BD Pharmingen™ Purified Mouse Anti-Human CD141 - Purified - Clone 1A4 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-Thrombomodulin antibody (ABIN2688974)

Teasdale, Bird, Bird: "Internalization of the anticoagulant thrombomodulin is constitutive and does not require a signal in the cytoplasmic domain." in: Immunology and cell biology, Vol. 72, Issue 6, pp. 480-8, (1995) (PubMed).

Target Details for Thrombomodulin

Target: Thrombomodulin (THBD)

Alternative Name: CD141

Background: Synonyms: Thrombomodulin