Cadherin 5 antibody

Catalog No. ABIN2688978

The Rat Monoclonal anti-Cadherin 5 antibody has been validated for IP, FACS, IHC (fro) and BR. It is suitable to detect Cadherin 5 in samples from Mouse. There are 3+ publications available.

Quick Overview for Cadherin 5 antibody (ABIN2688978)

Target: Cadherin 5 (CDH5)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Cadherin 5 antibody is un-conjugated

Application: Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)

Clone: 11D4-1

Product Details anti-Cadherin 5 Antibody

Brand: BD Pharmingen™

Characteristics: The 11D4.1 antibody reacts with mouse VE-cadherin, a member of the cadherin family. VE-cadherin is an endothelial cell-specific, homophilic adhesion molecule. It is concentrated at interendothelial cells contacts and is thought to be involved in the maintenance of cell layer integrity. In vitro and in vivo studies indicate that the 11D.4 mAb interferes with VE-cadherin-mediated intercellular adhesion. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

BD Pharmingen™ Purified Rat Anti-Mouse CD144 - Purified - Clone 11D4.1 - Isotype Rat IgG2a, κ - Reactivity Ms - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse VE-Cadherin-Ig Fusion Protein

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-Cadherin 5 antibody (ABIN2688978)

Gotsch, Borges, Bosse, Böggemeyer, Simon, Mossmann, Vestweber: "VE-cadherin antibody accelerates neutrophil recruitment in vivo." in: Journal of cell science, Vol. 110 ( Pt 5), pp. 583-8, (1997) (PubMed).

Breier, Breviario, Caveda, Berthier, Schnürch, Gotsch, Vestweber, Risau, Dejana: "Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system." in: Blood, Vol. 87, Issue 2, pp. 630-41, (1996) (PubMed).

Lampugnani, Resnati, Raiteri, Pigott, Pisacane, Houen, Ruco, Dejana: "A novel endothelial-specific membrane protein is a marker of cell-cell contacts." in: The Journal of cell biology, Vol. 118, Issue 6, pp. 1511-22, (1992) (PubMed).

Target Details for Cadherin 5

Target: Cadherin 5 (CDH5)

Alternative Name: CD144

Background: Synonyms: VE-Cadherin, Cadherin-5

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2