LY75/DEC-205 antibody

Catalog No. ABIN2689082

This Mouse Monoclonal antibody specifically detects LY75/DEC-205 in FACS. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for LY75/DEC-205 antibody (ABIN2689082)

Target: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LY75/DEC-205 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: MG38

Product Details anti-LY75/DEC-205 Antibody

Brand: BD Pharmingen™

Characteristics: Reacts with DEC-205, a 205 kDa transmembrane protein with C-type lectin external domains, present on dendritic cells (DC) and some epithelia. It is being described as a multilectin receptor for adsorptive endocytosis. MG38 antibody reacted with mature monocyte-derived DC and also with B cells, monocytes and weakly on T cells and NK cells. Antibody MG38 is useful for the study of DC development. Profile of CD205 (DEC-205), clone MG38, reactivity on monocyte-derived cultured dendritic cells analyzed by flow cytometry. Second step staining with FITC Goat Anti-Mouse IgG/IgM (Cat. No. 555988).

BD Pharmingen™ Purified Mouse Anti-Human CD205 - Purified - Clone MG38 - Isotype Mouse IgG2b - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-LY75/DEC-205 antibody (ABIN2689082)

Guo, Gong, Maric, Misulovin, Pack, Mahnke, Nussenzweig, Steinman: "A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells." in: Human immunology, Vol. 61, Issue 8, pp. 729-38, (2000) (PubMed).

Kato, Neil, Fearnley, McLellan, Vuckovic, Hart: "Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells." in: International immunology, Vol. 12, Issue 11, pp. 1511-9, (2000) (PubMed).

Kato, Neil, Clark, Morris, Sorg, Hart: "cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells." in: Immunogenetics, Vol. 47, Issue 6, pp. 442-50, (1998) (PubMed).

Target Details for LY75/DEC-205

Target: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Alternative Name: CD205

Background: Synonyms: DEC-205, Lymphocyte Antigen 75, CLEC13B