CD79a antibody

Catalog No. ABIN2689396

Cited in 2+ publications. This anti-CD79a antibody is a Mouse Monoclonal antibody detecting CD79a in ICS. Suitable for Human and Mouse.

Quick Overview for CD79a antibody (ABIN2689396)

Target: CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD79a antibody is un-conjugated

Application: Intracellular Staining (ICS)

Clone: HM47

Product Details anti-CD79a Antibody

Characteristics: Reacts with the cytoplasmic domain of a 47 kDa membrane glycoprotein present on B lymphocytes, also referred to as mb-1. It is expressed on B cells at various stages of differentiation, from pre-B cell stage, probably before expression of cytoplasmic μ chain, to plasma cell stage, in which it is detected only in the cytoplasm. CD79a associates with CD79b to form part of the B-cell receptor complex. It has been suggested that CD79a may play a role in mediating the transport of IgM to the cell surface. This antibody has been found to react on permeabilized A20 cells (mouse B cell line). Profile of permeabilized peripheral blood lymphocytes with Cytofix/Cytoperm (Cat# 554714) analyzed on a FACScan

BD Pharmingen™ Purified Mouse Anti-Human CD79a - Purified - Clone HM47 - Isotype Mouse IgG1, κ - Reactivity Hu, Ms - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-CD79a antibody (ABIN2689396)

Mason, Cordell, Tse, van Dongen, van Noesel, Micklem, Pulford, Valensi, Comans-Bitter, Borst: "The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 11, pp. 2474-82, (1991) (PubMed).

Sakaguchi, Kashiwamura, Kimoto, Thalmann, Melchers: "B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties." in: The EMBO journal, Vol. 7, Issue 11, pp. 3457-64, (1989) (PubMed).

Target Details for CD79a

Target: CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))

Alternative Name: CD79a

Background: Synonyms: Igα, mb-1

Pathways: BCR Signaling