ZFYVE9 antibody (AA 71-170) (HRP)

Catalog No. ABIN2690008

This Rabbit Polyclonal antibody specifically detects ZFYVE9 in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for ZFYVE9 antibody (AA 71-170) (HRP) (ABIN2690008)

Target: ZFYVE9 (Zinc Finger, FYVE Domain Containing 9 (ZFYVE9))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFYVE9 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ZFYVE9 Antibody (HRP)

Binding Specificity: AA 71-170

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SARA

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ZFYVE9

Target: ZFYVE9 (Zinc Finger, FYVE Domain Containing 9 (ZFYVE9))

Alternative Name: SARA

Background:

Synonyms: NSP, SARA, MADHIP, SMADIP, PPP1R173, Zinc finger FYVE domain-containing protein 9, Mothers against decapentaplegic homolog-interacting protein, Madh-interacting protein, Novel serine protease, Receptor activation anchor, hSARA, Smad anchor for receptor activation, ZFYVE9

Background: Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.

Gene ID: 9372

UniProt: O95405

Pathways: Protein targeting to Nucleus