N-Cadherin antibody

Catalog No. ABIN2716943

This anti-N-Cadherin antibody is a Mouse Monoclonal antibody detecting N-Cadherin in WB, IHC and FACS. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for N-Cadherin antibody (ABIN2716943)

Target: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This N-Cadherin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 3B10

Product Details anti-N-Cadherin Antibody

Characteristics: Homo sapiens cadherin 2, type 1, N-cadherin (neuronal) (CDH2)

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human CDH2(NP_001783) produced in HEK293T cell.

Isotype: IgG2a

Application Details

Application Notes: WB 1:2000, IHC 1:150, FLOW 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-N-Cadherin antibody (ABIN2716943)

Zhang, He, Chen, Pan, Du, Zang, Wang, Tang, Li, Lu, Yao, Jin, Ma: "Chemotherapy enhances tumor vascularization via Notch signaling-mediated formation of tumor-derived endothelium in breast cancer." in: Biochemical pharmacology, Vol. 118, pp. 18-30, (2016) (PubMed).

Target Details for N-Cadherin

Target: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Alternative Name: CDH2

Background: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

Molecular Weight: 97.2 kDa

Gene ID: 1000

NCBI Accession: NM_001792

HGNC: 1000

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane