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Acetyl-CoA Carboxylase alpha antibody

ACACA Reactivity: Human, Rat, Mouse WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN271866
  • Target See all Acetyl-CoA Carboxylase alpha (ACACA) Antibodies
    Acetyl-CoA Carboxylase alpha (ACACA)
    Reactivity
    • 94
    • 49
    • 48
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 91
    • 4
    • 1
    Rabbit
    Clonality
    • 87
    • 9
    Polyclonal
    Conjugate
    • 48
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Acetyl-CoA Carboxylase alpha antibody is un-conjugated
    Application
    • 83
    • 35
    • 26
    • 22
    • 14
    • 14
    • 9
    • 8
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of Acetyl-CoA Carboxylase protein. (region surrounding His74)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography using epitope-specific immunogen.
    Top Product
    Discover our top product ACACA Primary Antibody
  • Application Notes
    ELISA: 1/5000-1/10000. Western blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Acetyl-CoA Carboxylase alpha (ACACA)
    Alternative Name
    Acetyl-CoA Carboxylase 1 (ACACA Products)
    Synonyms
    ACAC antibody, ACACAD antibody, ACC antibody, ACC1 antibody, ACCA antibody, A530025K05Rik antibody, Acac antibody, Acc1 antibody, Gm738 antibody, AT-ACC1 antibody, EMB22 antibody, EMBRYO DEFECTIVE 22 antibody, GK antibody, GURKE antibody, PAS3 antibody, PASTICCINO 3 antibody, acetyl-CoA carboxylase 1 antibody, acc antibody, fj43d01 antibody, im:7138837 antibody, si:ch211-199d18.1 antibody, wu:fj43d01 antibody, acetyl-CoA carboxylase alpha antibody, acetyl-Coenzyme A carboxylase alpha antibody, acetyl-CoA carboxylase 1 antibody, ACACA antibody, Acaca antibody, ACC1 antibody, acaca antibody
    Background
    Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the ratelimiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACC-alpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC-beta (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACC-alpha is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted Serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the short-term regulatory mechanism of the enzyme. The gene encoding ACC-alpha, which maps to human chromosome 17, encodes the 265 kDa alpha form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACC-beta is homologous to that of ACC-alpha except for an additional peptide of about 150 amino acids at the N-terminus.Synonyms: ACAC, ACACA, ACC1, ACCA
    Molecular Weight
    approx. 265 kDa
    Gene ID
    31
    NCBI Accession
    NP_942131
    UniProt
    Q13085
    Pathways
    AMPK Signaling, Ribonucleoside Biosynthetic Process, Warburg Effect
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