SAMHD1 antibody

Catalog No. ABIN2731369

Product Details anti-SAMHD1 Antibody

Target: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SAMHD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Characteristics: Homo sapiens SAM domain and HD domain 1 (SAMHD1)

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human SAMHD1 (NP_056289) produced in HEK293T cell.

Clone: 2D7

Isotype: IgG2b

Application Details

Application Notes: WB 1:2000, IF 1:100, FLOW 1:100

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-SAMHD1 antibody (ABIN2731369)

Jeong, Park, Ahn, Ahn: "Inhibition of hepatitis B virus replication by a dNTPase-dependent function of the host restriction factor SAMHD1." in: Virology, Vol. 495, pp. 71-8, (2016) (PubMed).

Hertoghs, van der Aar, Setiawan, Kootstra, Gringhuis, Geijtenbeek: "SAMHD1 degradation enhances active suppression of dendritic cell maturation by HIV-1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 9, pp. 4431-7, (2015) (PubMed).

Pan, Pan, Weng, Zhao, Zhang, Wang, Lv, Jiang, Zheng, Xia: "Annexin A3 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma." in: Molecular carcinogenesis, Vol. 54, Issue 8, pp. 598-607, (2015) (PubMed).

Zhang, Bloch, Nguyen, Kim, Landau: "SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells." in: PLoS ONE, Vol. 9, Issue 2, pp. e89558, (2014) (PubMed).

Target Details for SAMHD1

Target: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Alternative Name: SAMHD1 (SAMHD1 Products)

Background: This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. COMPLETENESS: complete on the 3' end.

Molecular Weight: 72 kDa

Gene ID: 25939

NCBI Accession: NM_015474

HGNC: 25939