PLGF antibody (AA 206-221)

Catalog No. ABIN2743614

This anti-PLGF antibody is a Rabbit Polyclonal antibody detecting PLGF in WB. Suitable for Human, Chimpanzee and Monkey.

Quick Overview for PLGF antibody (AA 206-221) (ABIN2743614)

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Reactivity: Human, Chimpanzee, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLGF antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PLGF Antibody

Binding Specificity: AA 206-221

Specificity: Human PGF / PLGF

Purification: Immunoaffinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human PLGF(206-221aa REKMKPERCGDAVPRR). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Monkey (100%), Cat (88%).

Type of Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Approved: WB (0.5 - 1 μg/mL)

Usage: Placental growth factor(PGF, also known as PLGF) codes for an angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor(VPF/VEGF). It is a glycosylated dimeric secreted protein able to stimulate endothelial cell growth in vitro. PGF is located on chromosome 14 and has been conserved in evolution. It belongs to the family of vascular endothelial growth factors(VEGFs) and binds to the flt-1 VEGF receptor. PLGF-2, which is a PLGF isoform, binds neuropilin-1 and 2 in a heparin-dependent manner. PGF regulates inter- and intra molecular cross talk between the VEGF RTKs Flt1 and Flk1 and stimulates the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes. Moreover, it plays an important role in pathological angiogenic events and with exerting its biological activities through binding to VEGFR1.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Sterile distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS, 2.5 % BSA, 0.025 % sodium azide/thimerosal.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.

Target Details for PLGF

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Alternative Name: PGF / PLGF

Background: Name/Gene ID: PGF
Family: PDGF

Synonyms: PGF, D12S1900, PGFL, PlGF-2, Placental growth factor, Placental growth factor-like, PLGF, Placenta growth factor, SHGC-10760

Gene ID: 5228

Pathways: VEGFR1 Specific Signals