ACVR2B antibody (Extracellular Domain)

Catalog No. ABIN2745505

This anti-ACVR2B antibody is a Rabbit Polyclonal antibody detecting ACVR2B in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for ACVR2B antibody (Extracellular Domain) (ABIN2745505)

Target: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVR2B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ACVR2B Antibody

Binding Specificity: Extracellular Domain

Specificity: Recognizes the extracellular domain of human and mouse ACTR-IIB.

Cross-Reactivity: Human, Mouse (Murine)

Cross-Reactivity (Details): Does not cross-react with related human proteins ActR-IIecd, BMPR-IIecd, BMPR-IAecd, BMPR-IBecd or ActR-Iecd.

Purification: Antigen affinity purified.

Immunogen: Recombinant extracellular domain (ecd) of mouse activin receptor IIB.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS with 1 mg/mL BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for ACVR2B

Target: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Alternative Name: Activin Receptor IIB

Background: Activin Receptor IIB (ACTR-IIB) is a transmembrane receptor that forms an activin receptor complex with activin type-1 receptors (ACVR1, ACVR1B or ACVR1c). ACTR-IIB transduces the activin signal from the cell surface to the cytoplasm and regulates therefore many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary.

UniProt: P27040

Pathways: Hormone Transport, Cancer Immune Checkpoints