PDE4A antibody

Catalog No. ABIN2747099

This Rabbit Polyclonal antibody specifically detects PDE4A in WB, IHC, IF, ELISA, IP, ICC and CM. It exhibits reactivity toward Human, Mouse, Rat, Chicken and Monkey and has been mentioned in 13+ publications.

Quick Overview for PDE4A antibody (ABIN2747099)

Target: PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))

Reactivity: Human, Mouse, Rat, Chicken, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE4A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Immunoprecipitation (IP), Immunocytochemistry (ICC), Confocal Microscopy (CM)

Product Details anti-PDE4A Antibody

Purification: Affinity Purified

Immunogen: Synthetic peptide common to most PDE4 subtypes: PDE4A, PDE4D, PDE4B

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.62 μg/μL

References for anti-PDE4A antibody (ABIN2747099)

Lee, Shin, Hong: "The Regulatory Role of Rolipram on Inflammatory Mediators and Cholinergic/Adrenergic Stimulation-Induced Signals in Isolated Primary Mouse Submandibular Gland Cells." in: Mediators of inflammation, Vol. 2016, pp. 3745961, (2017) (PubMed).

Wang, Zhang, Liu, Zhao, Zhang, Yuan, An, Li, Wang, Qin, Wilson, ODonnell, Zhang, Li: "RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects." in: British journal of pharmacology, Vol. 168, Issue 4, pp. 1001-14, (2013) (PubMed).

Castiglione, Bergamini, Russo, La Croce, Castagna, Colciago, Salonia, Rigatti, Montorsi, Hedlund: "Inhibition of phosphodiesterase 4 enhances clitoral and vaginal blood flow responses to dorsal clitoral nerve stimulation or PGE1 in anesthetized female rats." in: The journal of sexual medicine, Vol. 10, Issue 4, pp. 939-50, (2013) (PubMed).

Muzaffar, Jeremy, Angelini, Shukla: "NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells." in: Journal of cellular physiology, Vol. 227, Issue 5, pp. 1941-50, (2012) (PubMed).

Li, Cheng, Huang, Conti, Wilson, ODonnell, Zhang: "Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 1, pp. 172-83, (2011) (PubMed).

Yagi, Tada, Kitazato, Tamura, Satomi, Nagahiro: "Ibudilast inhibits cerebral aneurysms by down-regulating inflammation-related molecules in the vascular wall of rats." in: Neurosurgery, Vol. 66, Issue 3, pp. 551-9; discussion 559, (2010) (PubMed).

Dodd-o, Hristopoulos, Kibler, Gutkowska, Mukaddam-Daher, Gonzalez, Welsh-Servinsky, Pearse: "The role of natriuretic peptide receptor-A signaling in unilateral lung ischemia-reperfusion injury in the intact mouse." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 294, Issue 4, pp. L714-23, (2008) (PubMed).

Uckert, Oelke, Stief, Andersson, Jonas, Hedlund: "Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate." in: European urology, Vol. 49, Issue 4, pp. 740-5, (2007) (PubMed).

Ückert, Oelke, Albrecht, Stief, Jonas, Hedlund: "Immunohistochemical description of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human labia minora." in: The journal of sexual medicine, Vol. 4, Issue 3, pp. 602-608, (2007) (PubMed).

Creighton, Zhu, Alexeyev, Stevens: "Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation." in: Journal of cell science, Vol. 121, Issue Pt 1, pp. 110-9, (2007) (PubMed).

Oelke, Hedlund, Albrecht, Ellinghaus, Stief, Jonas, Andersson, Uckert: "Expression of cAMP and cGMP-phosphodiesterase isoenzymes 3, 4, and 5 in the human clitoris: immunohistochemical and molecular biology study." in: Urology, Vol. 67, Issue 5, pp. 1111-6, (2006) (PubMed).

Uckert, Hedlund, Waldkirch, Sohn, Jonas, Andersson, Stief: "Interactions between cGMP- and cAMP-pathways are involved in the regulation of penile smooth muscle tone." in: World journal of urology, Vol. 22, Issue 4, pp. 261-6, (2005) (PubMed).

Uckert, Oelke, Waldkirch, Stief, Albrecht, Tröger, Jonas, Andersson, Hedlund: "Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves." in: Urology, Vol. 65, Issue 3, pp. 604-10, (2005) (PubMed).

Target Details for PDE4A

Target: PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))

Alternative Name: PDE4

Pathways: cAMP Metabolic Process