PDE4A antibody

Catalog No. ABIN2750880

This Rabbit Polyclonal antibody specifically detects PDE4A in WB, IHC, IF, ELISA, IP, ICC and CM. It exhibits reactivity toward Human, Mouse, Rat and Elk and has been mentioned in 37+ publications.

Quick Overview for PDE4A antibody (ABIN2750880)

Target: PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))

Reactivity: Human, Mouse, Rat, Elk

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE4A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Immunoprecipitation (IP), Immunocytochemistry (ICC), Confocal Microscopy (CM)

Product Details anti-PDE4A Antibody

Purification: Affinity Purified

Immunogen: Synthetic cyclic peptide common to all PDE4A proteins.

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.65-1.00 μg/μL

References for anti-PDE4A antibody (ABIN2750880)

Avila, Barker, Zhang, McClain, Barve, Gobejishvili: "Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis." in: The Journal of pathology, Vol. 240, Issue 1, pp. 96-107, (2017) (PubMed).

Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Kedia, Ückert, Oelke, Sonnenberg, Sohn, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human male urethra." in: Urology, Vol. 85, Issue 4, pp. 964.e1-6, (2015) (PubMed).

Yougbaré, Boire, Roy, Lugnier, Rouseau: "NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production." in: Canadian journal of physiology and pharmacology, Vol. 91, Issue 5, pp. 353-61, (2014) (PubMed).

Guo, Lin, Zhao, Zhang, Wei, Wang, Wang: "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." in: Neuroscience, Vol. 263, pp. 1-14, (2014) (PubMed).

Zhai, Chang, Wei, Liu, Leblais, Fischmeister, Ji: "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." in: Cellular signalling, Vol. 26, Issue 5, pp. 1001-10, (2014) (PubMed).

Vang, Housley, Dong, Basole, Ben-Sasson, Kream, Epstein, Clark, Brocke: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).

Ückert, Waldkirch, Sonnenberg, Sandner, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human seminal vesicles." in: The journal of sexual medicine, Vol. 8, Issue 11, pp. 3058-65, (2012) (PubMed).

Waldkirch, Ückert, Sigl, Satzger, Geismar, Langnäse, Richter, Sohn, Kuczyk, Hedlund: "Expression of cyclic AMP-dependent protein kinase isoforms in human cavernous arteries: functional significance and relation to phosphodiesterase type 4." in: The journal of sexual medicine, Vol. 7, Issue 6, pp. 2104-2111, (2011) (PubMed).

Abusnina, Alhosin, Keravis, Muller, Fuhrmann, Bronner, Lugnier: "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." in: Cellular signalling, Vol. 23, Issue 1, pp. 152-60, (2011) (PubMed).

Yougbare, Morin, Senouvo, Sirois, Albadine, Lugnier, Rousseau: "NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 4, pp. L441-50, (2011) (PubMed).

Vedin, Eriksson, Berghard: "Organization of the chemosensory neuroepithelium of the vomeronasal organ of the Scandinavian moose Alces alces." in: Brain research, Vol. 1306, pp. 53-61, (2010) (PubMed).

Fatemi, Folsom, Reutiman, Braun, Lavergne: "Levels of phosphodiesterase 4A and 4B are altered by chronic treatment with psychotropic medications in rat frontal cortex." in: Synapse (New York, N.Y.), Vol. 64, Issue 7, pp. 550-5, (2010) (PubMed).

Waldkirch, Uckert, Sigl, Langnaese, Richter, Stief, Kuczyk, Hedlund: "Expression of cAMP-dependent protein kinase isoforms in the human prostate: functional significance and relation to PDE4." in: Urology, Vol. 76, Issue 2, pp. 515.e8-14, (2010) (PubMed).

Fatemi, Reutiman, Folsom, Lee: "Phosphodiesterase-4A expression is reduced in cerebella of patients with bipolar disorder." in: Psychiatric genetics, Vol. 18, Issue 6, pp. 282-8, (2009) (PubMed).

Hörnberg, Gussing, Berghard, Bohm: "Retinoic acid selectively inhibits death of basal vomeronasal neurons during late stage of neural circuit formation." in: Journal of neurochemistry, Vol. 110, Issue 4, pp. 1263-75, (2009) (PubMed).

Liu, Fraser, Koos: "Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway." in: The Journal of comparative neurology, Vol. 516, Issue 1, pp. 36-48, (2009) (PubMed).

Zhang, Huang, Masood, Stolinski, Li, Zhang, Dlaboga, Jin, Conti, ODonnell: "Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 33, Issue 7, pp. 1611-23, (2008) (PubMed).

Braun, Reutiman, Lee, Folsom, Fatemi: "Expression of phosphodiesterase 4 is altered in the brains of subjects with autism." in: Neuroreport, Vol. 18, Issue 17, pp. 1841-4, (2008) (PubMed).

Target Details for PDE4A

Target: PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))

Alternative Name: PDE4A

UniProt: P27815

Pathways: cAMP Metabolic Process