CCR3 antibody (APC)

Catalog No. ABIN2752003

Cited in 1 publication. The APC-conjugated Mouse Monoclonal anti-CCR3 antibody (Clone 5E8) (ABIN2752003) specifically detects CCR3 in FACS. The antibody is reactive with Human samples.

Quick Overview for CCR3 antibody (APC) (ABIN2752003)

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCR3 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: 5E8

Product Details anti-CCR3 Antibody (APC)

Purpose: Anti-Hu CD193 APC

Cross-Reactivity (Details): Human

Characteristics: The mouse monoclonal antibody 5E8 recognizes an extracellular epitope of CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils.

Purification: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: human CD193 transfectants

Isotype: IgG2b, kappa

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze,Protect from prolonged exposure to light

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

References for anti-CCR3 antibody (APC) (ABIN2752003)

Morshed, Hlushchuk, Simon, Walls, Obata-Ninomiya, Karasuyama, Djonov, Eggel, Kaufmann, Simon, Yousefi: "NADPH oxidase-independent formation of extracellular DNA traps by basophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 11, pp. 5314-23, (2014) (PubMed).

Target Details for CCR3

Target: CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))

Alternative Name: CD193

Background: C-C motif chemokine receptor 3,CD193 / CCR3 is a G-protein coupled receptor for several chemokines, namely CCL11 (eotaxin), CCL26 (eotaxin-3), CCL7 (MCP-4), or CCL5 (RANTES). It is highly expressed on eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. CD193 is the key eosinophil chemokine receptor responsible for regulation of eosinophil migration and function. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1.,CCR3, CKR3, CMKBR3, CC-CKR-3

Gene ID: 1232

UniProt: P51677