Fusion Glycoprotein F0 (AA 136-608) antibody (Biotin)

Catalog No. ABIN2754557

This anti- antibody is a Rabbit Polyclonal antibody detecting in ELISA and WB. Suitable for Canine Distemper Virus (CDV).

Quick Overview for Fusion Glycoprotein F0 (AA 136-608) antibody (Biotin) (ABIN2754557)

Target: Fusion Glycoprotein F0

Reactivity: Canine Distemper Virus (CDV)

Host: Rabbit

Clonality: Polyclonal

Conjugate: Biotin

Application: ELISA, Western Blotting (WB)

Product Details

Binding Specificity: AA 136-608

Purification: Caprylic Acid Ammonium Sulfate Precipitation

Immunogen: Recombinant Canine distemper virus Fusion glycoprotein F0 protein(136-608aa)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C/-80 °C

Target Details

Target: Fusion Glycoprotein F0

Target Type: Viral Protein

Background: Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis.

UniProt: P12569