SEPN1 antibody (C-Term)

Catalog No. ABIN2773903

This anti-SEPN1 antibody is a Rabbit Polyclonal antibody detecting SEPN1 in WB and IHC. Suitable for Human, Mouse, Cow, Guinea Pig, Horse, Rat and Zebrafish (Danio rerio).

Quick Overview for SEPN1 antibody (C-Term) (ABIN2773903)

Target: SEPN1 (Selenoprotein N, 1 (SEPN1))

Reactivity: Human, Mouse, Cow, Guinea Pig, Horse, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEPN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SEPN1 Antibody

Binding Specificity: C-Term

Sequence: ANYFLDITSV KPEEIESNLF SFSSTFEDPS TATYMQFLKE GLRRGLPLLQ

Predicted Reactivity: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against SEPN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SEPN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 590 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SEPN1

Target: SEPN1 (Selenoprotein N, 1 (SEPN1))

Alternative Name: SEPN1

Background: SEPN1 is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. Mutations in SEPN1 gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Mutations in this gene cause the classical phenotype of multiminicore disease and congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: FLJ24021, MDRS1, RSMD1, RSS, SELN, CFTD
Protein Interaction Partner: ELAVL1, UBC,
Protein Size: 590

Molecular Weight: 62 kDa

Gene ID: 57190

NCBI Accession: NM_020451, NP_065184

UniProt: Q9NZV5

Pathways: Skeletal Muscle Fiber Development