MRVI1 antibody (N-Term)

Catalog No. ABIN2773963

This Rabbit Polyclonal antibody specifically detects MRVI1 in WB. It exhibits reactivity toward Human, Cow, Dog, Guinea Pig, Horse, Mouse, Rabbit and Rat.

Quick Overview for MRVI1 antibody (N-Term) (ABIN2773963)

Target: MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))

Reactivity: Human, Cow, Dog, Guinea Pig, Horse, Mouse, Rabbit, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRVI1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MRVI1 Antibody

Binding Specificity: N-Term

Sequence: LVNDQLPDIS ISEEDKKKNL ALLEEAKLVS ERFLTRRGRK SRSSPGDSPS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MRVI1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MRVI1

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MRVI1

Target: MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))

Alternative Name: MRVI1

Background: This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
Protein Interaction Partner: MME, PRKG1, ITPR1,
Protein Size: 803

Molecular Weight: 88 kDa

Gene ID: 10335