CTDSP2 antibody (Middle Region)

Catalog No. ABIN2774003

The Rabbit Polyclonal anti-CTDSP2 antibody is suitable to detect CTDSP2 in samples from Human, Rat, Mouse, Cow, Horse, Guinea Pig, Rabbit, Dog and Pig. It has been validated for WB.

Quick Overview for CTDSP2 antibody (Middle Region) (ABIN2774003)

Target: CTDSP2 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 (CTDSP2))

Reactivity: Human, Rat, Mouse, Cow, Horse, Guinea Pig, Rabbit, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTDSP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CTDSP2 Antibody

Binding Specificity: Middle Region

Sequence: ASYIFHPENA VPVQSWFDDM ADTELLNLIP IFEELSGAED VYTSLGQLRA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 91%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CTDSP2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CTDSP2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 271 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CTDSP2

Target: CTDSP2 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 (CTDSP2))

Alternative Name: CTDSP2

Background: CTDSP2 preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A.CTDSP2 negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. CTDSP2 is recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.CTDSP2 may contribute to the development of sarcomas.
Alias Symbols: OS4, PSR2, SCP2
Protein Interaction Partner: CDCA3, UBC, AR, SNAI1, POLR2A,
Protein Size: 271

Molecular Weight: 31 kDa

Gene ID: 10106

NCBI Accession: NM_005730, NP_005721

UniProt: O14595

Pathways: ER-Nucleus Signaling