FRS3 antibody (Middle Region)

Catalog No. ABIN2774008

The Rabbit Polyclonal anti-FRS3 antibody (ABIN2774008) specifically detects FRS3 in WB. The antibody is reactive with Human, Rat, Mouse, Dog, Horse, Rabbit, Cow, Guinea Pig and Pig samples.

Quick Overview for FRS3 antibody (Middle Region) (ABIN2774008)

Target: FRS3 (Fibroblast Growth Factor Receptor Substrate 3 (FRS3))

Reactivity: Human, Rat, Mouse, Dog, Horse, Rabbit, Cow, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRS3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FRS3 Antibody

Binding Specificity: Middle Region

Sequence: GFPDGEEDET PLQKPTSTRA AIRSHGSFPV PLTRRRGSPR VFNFDFRRPG

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against FRS3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FRS3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 492 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FRS3

Target: FRS3 (Fibroblast Growth Factor Receptor Substrate 3 (FRS3))

Alternative Name: FRS3

Background: FRS3 is an adapter protein that links FGR and NGF receptors to downstream signaling pathways. FRS3 is involved in the activation of MAP kinases. FRS3 down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FRS2B, FRS2beta, MGC17167, SNT-2, SNT2
Protein Interaction Partner: NOTCH2NL, RFX6, SPERT, ADAMTSL4, SH3KBP1, CD2AP, SPRY2, TRIP6, TCF4, PLSCR1, GATA1, ERBB2, CBL, AES, ELAVL1, RND1, KARS, BMPR2, NTRK2, PRKCI, NTRK1, MAPK1, PTPN11, FGFR1, GRB2,
Protein Size: 492

Molecular Weight: 54 kDa

Gene ID: 10817

NCBI Accession: NM_006653, NP_006644

UniProt: O43559