FBXL14 antibody (N-Term)

Catalog No. ABIN2774033

This anti-FBXL14 antibody is a Rabbit Polyclonal antibody detecting FBXL14 in WB. Suitable for Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for FBXL14 antibody (N-Term) (ABIN2774033)

Target: FBXL14 (F-Box and Leucine-Rich Repeat Protein 14 (FBXL14))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL14 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FBXL14 Antibody

Binding Specificity: N-Term

Sequence: WRDAAYHKSV WRGVEAKLHL RRANPSLFPS LQARGIRRVQ ILSLRRSLSY

Predicted Reactivity: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against FBXL14. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FBXL14

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 418 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FBXL14

Target: FBXL14 (F-Box and Leucine-Rich Repeat Protein 14 (FBXL14))

Alternative Name: FBXL14

Background: FBXL14 is a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1, MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].
Alias Symbols: Fbl14, MGC40195
Protein Interaction Partner: DICER1, HSP90AA1, COPS5, COPS6, CUL1, Snai1,
Protein Size: 418

Molecular Weight: 46 kDa

Gene ID: 144699

NCBI Accession: NM_152441, NP_689654

UniProt: Q8N1E6