USP21 antibody (N-Term)

Catalog No. ABIN2774072

The Rabbit Polyclonal anti-USP21 antibody has been validated for WB. It is suitable to detect USP21 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse and Rabbit.

Quick Overview for USP21 antibody (N-Term) (ABIN2774072)

Target: USP21 (Ubiquitin Specific Peptidase 21 (USP21))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP21 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-USP21 Antibody

Binding Specificity: N-Term

Sequence: PLPPRPGPPD ERLKKLELGR GRTSGSRPRG PLRADHGVPL PGSPPPAVAL

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Usp21. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Usp21

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 566 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for USP21

Target: USP21 (Ubiquitin Specific Peptidase 21 (USP21))

Alternative Name: Usp21

Background: Usp21 deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Usp21 regulates gene expression via histone H2A deubiquitination. It is also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.
Alias Symbols: ESTM28, Usp16, Usp23, W53272
Protein Interaction Partner: Eed, TGFBR1, ACVR1,
Protein Size: 566

Molecular Weight: 62 kDa

Gene ID: 30941

NCBI Accession: NM_013919, NP_038947

UniProt: Q9QZL6