FBXO22 antibody (Middle Region)

Catalog No. ABIN2774089

This Rabbit Polyclonal antibody specifically detects FBXO22 in WB. It exhibits reactivity toward Human, Mouse, Dog, Rabbit, Rat, Horse, Cow and Guinea Pig.

Quick Overview for FBXO22 antibody (Middle Region) (ABIN2774089)

Target: FBXO22 (F-Box Protein 22 (FBXO22))

Reactivity: Human, Mouse, Dog, Rabbit, Rat, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO22 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FBXO22 Antibody

Binding Specificity: Middle Region

Sequence: CCKVGASNYL QQVVSTFSDM NIILAGGQVD NLSSLTSEKY VLCASDFVCE

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 79%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against FBXO22. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FBXO22

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 276 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FBXO22

Target: FBXO22 (F-Box Protein 22 (FBXO22))

Alternative Name: FBXO22

Background: FBXO22 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXO22 belongs to the Fbxs class. Two transcript variants encoding different isoforms exist for this gene.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Two transcript variants encoding different isoforms exist for this gene.
Alias Symbols: FBX22, FLJ13986, MGC31799, FISTC1
Protein Interaction Partner: Srr, UBC, CUL1, SKP1, NEDD8, COPS5, COPS6, RBX1,
Protein Size: 276

Molecular Weight: 30 kDa

Gene ID: 26263

NCBI Accession: NM_012170, NP_036302

UniProt: Q8NEZ5

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development