Spastin antibody (Middle Region)

Catalog No. ABIN2774193

This anti-Spastin antibody is a Rabbit Polyclonal antibody detecting Spastin in WB. Suitable for Mouse, Rat, Human, Guinea Pig, Horse, Rabbit, Cow, Dog, Goat and Zebrafish (Danio rerio).

Quick Overview for Spastin antibody (Middle Region) (ABIN2774193)

Target: Spastin (SPAST)

Reactivity: Mouse, Rat, Human, Guinea Pig, Horse, Rabbit, Cow, Dog, Goat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Spastin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Spastin Antibody

Binding Specificity: Middle Region

Sequence: RVLVMGATNR PQELDEAVLR RFIKRVYVSL PNEETRLLLL KNLLCKQGSP

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against SPAST. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human SPAST

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Spastin

Target: Spastin (SPAST)

Alternative Name: SPAST

Background: This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4.
Protein Interaction Partner: HECW2, ALB, VCP, CHMP1B, IST1, ELAVL1, SSNA1, RTN1,
Protein Size: 498

Molecular Weight: 54 kDa

Gene ID: 6683

Pathways: Microtubule Dynamics, M Phase, Regulation of Cell Size