Adenylosuccinate Lyase antibody (Middle Region)

Catalog No. ABIN2774275

The Rabbit Polyclonal anti-Adenylosuccinate Lyase antibody has been validated for WB and IHC. It is suitable to detect Adenylosuccinate Lyase in samples from Human, Mouse, Rat, Dog, Rabbit, Guinea Pig, Horse, Cow, Pig and Sheep.

Quick Overview for Adenylosuccinate Lyase antibody (Middle Region) (ABIN2774275)

Target: Adenylosuccinate Lyase (ADSL)

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Guinea Pig, Horse, Cow, Pig, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adenylosuccinate Lyase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Adenylosuccinate Lyase Antibody

Binding Specificity: Middle Region

Sequence: RVRDDLRFRG VKGTTGTQAS FLQLFEGDDH KVEQLDKMVT EKAGFKRAFI

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 86%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against ADSL. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ADSL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 484 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Adenylosuccinate Lyase

Target: Adenylosuccinate Lyase (ADSL)

Alternative Name: ADSL

Background: Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: AMPS, ASASE, ASL
Protein Interaction Partner: CALCOCO2, REL, UBC, PDE12, BTF3L4, NPLOC4, EHD4, UBQLN2, NT5C2, WDR4, PAIP1, PLIN3, SAE1, OXSR1, API5, XPNPEP1, WARS, RAD23B, TWF1, DNAJB1, GTF2I, EIF1AX, DRG2, CTSC, NOV, TYMS, SUMO1, DDA1, USP15, USP4,
Protein Size: 484

Molecular Weight: 55 kDa

Gene ID: 158

NCBI Accession: NM_000026, NP_000017

UniProt: P30566

Pathways: Ribonucleoside Biosynthetic Process