TNIP1 antibody (C-Term)

Catalog No. ABIN2774321

The Rabbit Polyclonal anti-TNIP1 antibody has been validated for WB. It is suitable to detect TNIP1 in samples from Human, Horse and Dog.

Quick Overview for TNIP1 antibody (C-Term) (ABIN2774321)

Target: TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))

Reactivity: Human, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNIP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TNIP1 Antibody

Binding Specificity: C-Term

Sequence: NSRLFHLPEY TWRLPCGGVR NPNQSSQVMD PPTARPTEPE SPKNDREGPQ

Predicted Reactivity: Dog: 92%, Horse: 86%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against TNIP1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 636 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TNIP1

Target: TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))

Alternative Name: TNIP1

Background: TNIP1 interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal. TNIP1 increases cell surface CD4(T4) antigen expression. TNIP1 interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. TNIP1 may regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production.
Alias Symbols: ABIN-1, KIAA0113, NAF1, VAN, nip40-1
Protein Interaction Partner: HDDC3, MAGEB18, CFAP53, TXLNA, CCDC112, MOB3C, SYT6, TCEANC2, MOB1B, MAP1LC3A, NIFK, FAM161A, MAP1LC3B, TNIP3, SNIP1, CDIP1, NME7, MAGEH1, GABARAPL2, PNKP, MORF4L1, RALBP1, ZNHIT1, NDC80, TNIP1, OPTN, MORF4L2, AP1M1, TAX1BP1, ZBTB25, UBC, TNFAIP3, TCEA2,
Protein Size: 636

Molecular Weight: 70 kDa

Gene ID: 10318

NCBI Accession: NM_006058, NP_006049

UniProt: Q15025

Pathways: Activation of Innate immune Response