Cathepsin L antibody (C-Term)

Catalog No. ABIN2774366

The Rabbit Polyclonal anti-Cathepsin L antibody has been validated for WB. It is suitable to detect Cathepsin L in samples from Human, Mouse, Rat and Sheep.

Quick Overview for Cathepsin L antibody (C-Term) (ABIN2774366)

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Reactivity: Human, Mouse, Rat, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin L antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Cathepsin L Antibody

Binding Specificity: C-Term

Sequence: GGLDSEESYP YEATEESCKY NPKYSVANDT GFVDIPKQEK ALMKAVATVG

Predicted Reactivity: Human: 100%, Mouse: 77%, Rat: 77%, Sheep: 77%

Characteristics: This is a rabbit polyclonal antibody against CTSL1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 333 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Cathepsin L

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Alternative Name: CTSL1

Background: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: CATL, CTSL, FLJ31037, MEP, CTSL1
Protein Interaction Partner: SGTA, SERPINB3, BTN3A3, RELB, PPP1CC, APOA1, ALB, UBC, EED, BAG6, GEM, ARSA, SERPINB13, CST3, CST7, CTSC, CSTB, KNG1, PLAU, TG, CD7, CSTA, RXRA, CXCL8, IGFBP3, CD74, GCG, COL18A1, CUX1, CTSL, SLPI,
Protein Size: 333

Molecular Weight: 36 kDa

Gene ID: 1514

NCBI Accession: NM_145918, NP_666023

UniProt: P07711

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades