PMM2 antibody (Middle Region)

Catalog No. ABIN2774385

The Rabbit Polyclonal anti-PMM2 antibody has been validated for WB. It is suitable to detect PMM2 in samples from Human, Mouse, Rat, Rabbit, Guinea Pig, Dog, Horse, Cow and Zebrafish (Danio rerio).

Quick Overview for PMM2 antibody (Middle Region) (ABIN2774385)

Target: PMM2 (Phosphomannomutase 2 (PMM2))

Reactivity: Human, Mouse, Rat, Rabbit, Guinea Pig, Dog, Horse, Cow, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PMM2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PMM2 Antibody

Binding Specificity: Middle Region

Sequence: IEFRNGMLNV SPIGRSCSQE ERIEFYELDK KENIRQKFVA DLRKEFAGKG

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%

Characteristics: This is a rabbit polyclonal antibody against PMM2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 246 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PMM2

Target: PMM2 (Phosphomannomutase 2 (PMM2))

Alternative Name: PMM2

Background: The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I.
Alias Symbols: CDG1, CDG1a, CDGS, PMM 2
Protein Interaction Partner: ACY3, SUMO2, UBC, TAGLN3,
Protein Size: 246

Molecular Weight: 28 kDa

Gene ID: 5373

NCBI Accession: NM_000303, NP_000294

UniProt: O15305