BDKRB1 antibody (C-Term)

Catalog No. ABIN2774418

The Rabbit Polyclonal anti-BDKRB1 antibody has been validated for WB. It is suitable to detect BDKRB1 in samples from Human, Rat, Mouse and Pig.

Quick Overview for BDKRB1 antibody (C-Term) (ABIN2774418)

Target: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Reactivity: Human, Rat, Mouse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BDKRB1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BDKRB1 Antibody

Binding Specificity: C-Term

Sequence: RTREEVSRTR CGGRKDSKTT ALILTLVVAF LVCWAPYHFF AFLEFLFQVQ

Predicted Reactivity: Human: 100%, Mouse: 92%, Pig: 79%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against BDKRB1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human BDKRB1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 353 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for BDKRB1

Target: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Alternative Name: BDKRB1

Background: Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: B1BKR, B1R, BKB1R, BKR1, BRADYB1
Protein Interaction Partner: GNAQ, MEP1A,
Protein Size: 353

Molecular Weight: 40 kDa

Gene ID: 623

NCBI Accession: NM_000710, NP_000701

UniProt: P46663

Pathways: ACE Inhibitor Pathway